After years of development, Virtual Microbes are finally starting to give us new biological insights. The first piece of work is now peer-reviewed and published, but if you have little time, see a video abstract of what we did right here:
As of today, it is 8 years ago that I presented a paper for a course, and I recently got reminded of this work. The paper, written by Espinosa-Soto et al. (2011)1 was about phenotypic plasticity (the same genotype giving rise to alternative phenotypes) and how it can help or hinder evolution. Since then, a lot of single-cell measurements have been done on microorganisms, revealing just how dominant phenotypic heterogeneity is in bacterial populations. For example, take a look at the awesome video by Alma Dal Co, revealing how microscale gradients in clonal populations give rise to cross-feeding and antibiotic tolerance:
I am a computational biologist studying microbial ecology and evolution with a key focus on horizontal gene transfer (HGT). This website is primarily dedicated to the science, the programming, and the visualisation of cool biological systems. However, it may also contain whatever else I feel like sharing.